Modeling brain disease in a dish: really?

Maria C Marchetto; Fred H Gage

doi:10.1016/j.stem.2012.05.008

Modeling brain disease in a dish: really?

Cell Stem Cell. 2012 Jun 14;10(6):642-645. doi: 10.1016/j.stem.2012.05.008.

Authors

Maria C Marchetto¹, Fred H Gage²

Affiliations

¹ Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
² Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: gage@salk.edu.

PMID: 22704498
DOI: 10.1016/j.stem.2012.05.008

Abstract

Cellular programming and reprogramming technology (CPART) presents a novel approach for understanding disease progression and mechanism. In addition, CPART provides an innovative opportunity for developing diagnostic tools and novel drug candidates for therapy. In this Forum, we will discuss obstacles and solutions for modeling brain disease using CPART.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Brain Diseases / therapy*
Disease Models, Animal*
Humans
Regenerative Medicine / methods*
Stem Cells / cytology*
Stem Cells / physiology*
Tissue Engineering