Hematopoietic stem cell heterogeneity takes center stage

Cell Stem Cell. 2012 Jun 14;10(6):690-697. doi: 10.1016/j.stem.2012.05.006.


Over the past 10 years, increasing evidence has accumulated that heterogeneity is a feature of hematopoietic stem cell (HSC) proliferation, self-renewal, and differentiation based on examination of these properties at a clonal level. The heterogeneous behavior of HSCs reflects the operation of a complex interplay of intrinsic and extrinsic variables. In this review, we discuss key findings from the last 5 years that reveal new insights into the mechanisms involved.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Differentiation*
  • Clone Cells / pathology*
  • Hematopoietic Stem Cell Transplantation*
  • Hematopoietic Stem Cells / cytology*
  • Hematopoietic Stem Cells / physiology*
  • Humans
  • Neoplasms / pathology*
  • Neoplasms / therapy*