Crohn's disease with pulmonary manifestations in children: 2 case reports and review of the literature

J Crohns Colitis. 2013 Apr;7(3):e85-92. doi: 10.1016/j.crohns.2012.05.007. Epub 2012 Jun 14.


Crohn's disease (CD) is a chronic granulomatous disease of unknown etiology that affects primarily the gastrointestinal system but can be associated with extraintestinal manifestations. Latent pulmonary involvement in children with CD has been described, but symptomatic pulmonary disease has rarely been reported in children. In this review, we report two pediatric cases, one with pleural effusion at the time of CD diagnosis and the other with bilateral cavitary lesions in a previously diagnosed CD patient. We review the current literature and summarize the diagnosis and management of pulmonary involvement in CD. Awareness of these pulmonary complications of CD in children may lead to more prompt diagnosis, guide appropriate therapy, and decrease morbidity.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adolescent
  • Child
  • Crohn Disease / complications*
  • Crohn Disease / diagnosis
  • Female
  • Granuloma, Respiratory Tract / diagnosis*
  • Granuloma, Respiratory Tract / etiology
  • Humans
  • Lung Diseases / diagnosis*
  • Lung Diseases / etiology

Supplementary concepts

  • Pediatric Crohn's disease