Impaired saccadic eye movement in primary open-angle glaucoma

J Glaucoma. 2014 Jan;23(1):23-32. doi: 10.1097/IJG.0b013e31825c10dc.


Purpose: Our study aimed at investigating the extent to which saccadic eye movements are disrupted in patients with primary open-angle glaucoma (POAG). This approach followed upon the discovery of differences in the eye-movement behavior of POAG patients during the exploration of complex visual scenes.

Methods: The eye movements of 8 POAG patients and 4 healthy age-matched controls were recorded. Four of the patients had documented visual field scotoma, and 4 had no identifiable scotoma on visual field testing. The eye movements were monitored as the observers watched static and kinetic targets. The gain, latency, and velocity-peak latency of the saccades recorded were then analyzed.

Results: In POAG patients, with abnormal visual fields, watching a static target, the saccades were delayed and their accuracy was reduced, compared with those of normal observers. In POAG patients, with normal and abnormal visual fields, watching a kinetic target, a task involving precise motion analysis, the latency and accuracy of the saccades were impaired, compared with those of normal observers.

Conclusions: Our findings suggest that POAG alters saccade programming and execution particularly in the case of moving targets.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Eye Movement Measurements
  • Female
  • Glaucoma, Open-Angle / complications*
  • Glaucoma, Open-Angle / physiopathology
  • Humans
  • Male
  • Middle Aged
  • Ocular Motility Disorders / etiology*
  • Ocular Motility Disorders / physiopathology
  • Saccades / physiology*
  • Scotoma / physiopathology
  • Visual Field Tests
  • Visual Fields / physiology