EG-VEGF: a key endocrine factor in placental development

Trends Endocrinol Metab. 2012 Oct;23(10):501-8. doi: 10.1016/j.tem.2012.05.006. Epub 2012 Jun 16.


Endocrine gland-derived vascular endothelial growth factor (EG-VEGF), also named prokineticin 1, is the canonical member of the prokineticin family. Numerous reports suggest a direct involvement of this peptide in normal and pathological reproductive processes. Recent advances propose EG-VEGF as a key endocrine factor that controls many aspects of placental development and suggest its involvement in the development of preeclampsia (PE), the most threatening pathology of human pregnancy. This review describes the finely tuned action and regulation of EG-VEGF throughout human pregnancy, argues for its clinical relevance as a potential diagnostic marker of the onset of PE, and discusses future research directions for therapeutic targeting of EG-VEGF.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Female
  • Humans
  • Models, Biological
  • Placentation / genetics
  • Placentation / physiology*
  • Pregnancy
  • Vascular Endothelial Growth Factor, Endocrine-Gland-Derived / genetics
  • Vascular Endothelial Growth Factor, Endocrine-Gland-Derived / metabolism*


  • Vascular Endothelial Growth Factor, Endocrine-Gland-Derived