Compliance with guidelines in patients with ST-segment elevation myocardial infarction after implementation of specific guidelines for emergency care: results of RESCA+31 registry

Arch Cardiovasc Dis. 2012 May;105(5):262-70. doi: 10.1016/j.acvd.2012.03.001. Epub 2012 May 22.


Background: Guidelines emphasize the implementation of local networks with prehospital emergency medical systems to improve the management of patients with ST-segment elevation myocardial infarction (STEMI); they also define the choice of reperfusion strategies and adjunctive treatments.

Aim: To assess the compliance of STEMI emergency care with current French guidelines in a large area of France and to identify predictors of compliance with guidelines.

Method: The RESCA+31 registry was a 2-year, multicentre, prospective, multidisciplinary study, including 512 consecutive patients with STEMI evolving within 12 hours managed by emergency physicians in the prehospital system or emergency department. Data were recorded during the emergency phase and after admission to cardiology.

Results: First medical contact (FMC) was prehospital emergency care for 80% of patients; 97% received reperfusion treatment and 98% were admitted to a cardiology intensive care unit (CICU) with a catheterization laboratory. The mortality rate was 5%. Guidelines were complied with in 41% of patients for reperfusion strategies, in 47% for adjunctive treatments and in 23% for both. The only factor independently associated with guideline compliance was FMC by prehospital emergency system. In 52% of cases, emergency physicians underestimated the delay between FMC and admission to a CICU.

Conclusion: Despite the implementation of a network, compliance with guidelines for reperfusion strategies and adjunctive treatments was insufficient in our area. However, very few patients did not receive reperfusion therapy and the mortality rate was low. Efforts should be made to improve the estimation of delay before primary percutaneous coronary intervention.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Angioplasty, Balloon, Coronary / standards
  • Cardiac Catheterization / standards
  • Chi-Square Distribution
  • Coronary Care Units / standards
  • Emergency Medical Services / standards
  • Emergency Service, Hospital / standards*
  • Female
  • France
  • Guideline Adherence / standards*
  • Health Services Research
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Myocardial Infarction / mortality
  • Myocardial Infarction / therapy*
  • Myocardial Reperfusion / adverse effects
  • Myocardial Reperfusion / mortality
  • Myocardial Reperfusion / standards*
  • Odds Ratio
  • Platelet Aggregation Inhibitors / therapeutic use
  • Practice Guidelines as Topic / standards*
  • Practice Patterns, Physicians' / standards*
  • Prospective Studies
  • Registries
  • Thrombolytic Therapy / standards
  • Time Factors
  • Treatment Outcome


  • Platelet Aggregation Inhibitors