[Oncogenes, Antioncogenes and Carcinogenesis]

Arkh Patol. 1990;52(9):3-11.
[Article in Russian]

Abstract

Current concepts on oncogenes, "antioncogenes" and their role in tumorigenesis are presented. Normal functions of proto-oncogenes, mechanisms of their conversion to oncogenes and inactivation of "antioncogenes", effects of oncogenes in model systems in vitro and in vivo are considered. Special attention is paid to the nonrandom proto-oncogene and "antioncogene" alterations in human tumours and the possibilities of their use as diagnostic or prognostic criteria.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Cell Transformation, Neoplastic / genetics
  • Cell Transformation, Viral / genetics
  • Gene Expression Regulation, Neoplastic / genetics
  • Gene Expression Regulation, Viral / genetics
  • Genes, Tumor Suppressor* / genetics
  • Humans
  • Neoplasms / etiology*
  • Neoplasms / genetics
  • Oncogenes* / genetics
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogenes / genetics
  • Retroviridae / genetics
  • Retroviridae / pathogenicity

Substances

  • Proto-Oncogene Proteins