Programmable bacterial catalysis - designing cells for biosynthesis of value-added compounds

FEBS Lett. 2012 Jul 16;586(15):2184-90. doi: 10.1016/j.febslet.2012.02.030. Epub 2012 Feb 25.


Bacteria have long been used for the synthesis of a wide range of useful proteins and compounds. The developments of new bioprocesses and improvements of existing strategies for syntheses of valuable products in various bacterial cell hosts have their own challenges and limitations. The field of synthetic biology has combined knowledge from different science and engineering disciplines and facilitated the advancement of novel biological components which has inspired the design of targeted biosynthesis. Here we discuss recent advances in synthetic biology with relevance to biosynthesis in bacteria and the applications of computational algorithms and tools for manipulation of cellular components. Continuous improvements are necessary to keep up with increasing demands in terms of complexity, scale, and predictability of biosynthesis products.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bacteria / cytology*
  • Bacteria / genetics
  • Bacteria / metabolism*
  • Biocatalysis*
  • Cells / metabolism*
  • Gene Regulatory Networks
  • Humans
  • Metabolic Networks and Pathways
  • Synthetic Biology / methods*