Comparative study of 5 % potassium hydroxide solution versus 0.05% tretinoin cream for Molluscum Contagiosum in children

Kathmandu Univ Med J (KUMJ). Oct-Dec 2011;9(36):291-4. doi: 10.3126/kumj.v9i4.6347.

Abstract

Background: Molluscum contagiosum is one of the commonest cutaneous viral infections in children. All treatment modalities are associated with substantial pain, tissue destruction, and frequent recurrence.

Objectives: To compare the efficacy and side effects of KOH 5% solution with tretinoin 0.05% cream for the treatment of molluscum contagiosum in children.

Methods: Fifty patients were randomly divided into 2 groups; 25 each for 5% KOH solution and 0.05% tretinoin cream. The given medication was applied at bed time over molluscum lesions. The assessment of response and side effects were performed weekly for 4 weeks.

Results: At the end of 4 weeks, the mean lesion count decreased from 9.48 +/- 3.00 SD to 1.67 +/- 0.58 SD and from 8.35 +/- 2.82 SD to 2.00 +/- 1.00 SD in patients treated with 5% KOH solution and 0.05% tretinoin cream respectively.

Conclusion: The result of both KOH and tretinoin showed good response, well tolerated by children but between the two, KOH showed fast recovery and most lesions were resolved before 4 week. The side effects could be minimized if applied as stated above. On the other hand, tretinoin showed delayed response and even some of lesion extended beyond 4 week but the side effect were less, and hence can be used in recurrent cases.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Administration, Cutaneous
  • Adolescent
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Hydroxides / administration & dosage
  • Hydroxides / adverse effects
  • Hydroxides / therapeutic use*
  • Infant
  • Keratolytic Agents / administration & dosage
  • Keratolytic Agents / adverse effects
  • Keratolytic Agents / therapeutic use*
  • Male
  • Molluscum Contagiosum / drug therapy*
  • Potassium Compounds / administration & dosage
  • Potassium Compounds / adverse effects
  • Potassium Compounds / therapeutic use*
  • Tretinoin / administration & dosage
  • Tretinoin / adverse effects
  • Tretinoin / therapeutic use*

Substances

  • Hydroxides
  • Keratolytic Agents
  • Potassium Compounds
  • Tretinoin
  • potassium hydroxide