Abstract
T-cell development and differentiation is coordinated by a multitude of signaling molecules and transcription factors that impart distinct functional properties to progenitors. In this review, we focus on the role of the T lineage-enriched chromatin organizer and regulator SATB1 in T-cell differentiation. SATB1 mediates Wnt signaling by recruiting β-catenin to its genomic targets and coordinates T helper type 2 (T(H)2) differentiation by positively regulating GATA-3. In contrast, maintenance of regulatory T cell (Treg) functions are dependent on inhibition of SATB1-mediated modulation of global chromatin organization. We discuss how regulation of the activity of SATB1 has a critical role in driving these two important differentiation pathways in T cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Differentiation / genetics
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Cell Differentiation / immunology*
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Chromatin / genetics
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Chromatin / immunology*
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Chromatin / metabolism
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GATA3 Transcription Factor / genetics
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GATA3 Transcription Factor / immunology
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GATA3 Transcription Factor / metabolism
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Gene Expression / immunology
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Humans
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Matrix Attachment Region Binding Proteins / genetics
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Matrix Attachment Region Binding Proteins / immunology*
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Matrix Attachment Region Binding Proteins / metabolism
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Models, Immunological
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T-Lymphocytes, Regulatory / immunology*
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T-Lymphocytes, Regulatory / metabolism
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Th2 Cells / immunology*
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Th2 Cells / metabolism
Substances
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Chromatin
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GATA3 Transcription Factor
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Matrix Attachment Region Binding Proteins
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SATB1 protein, human