Bone-vascular cross-talk

J Nephrol. Sep-Oct 2012;25(5):619-25. doi: 10.5301/jn.5000187.


Increasing numbers of cross-sectional studies on general populations and chronic kidney disease (CKD) or end-stage renal disease (ESRD) patients have reported relationships between cardiovascular calcifications and bone disorders, including osteoporosis, osteopenia and high or low bone activity. The mechanisms underlying this bone-cardiovascular axis and biological links between bone and arterial abnormalities are suggestive of bone-vascular cross-talk. The nature of these links is not well understood and could result from: 1) common factors acting on bone remodeling and arterial calcification; 2) compromised bone blood supply responsible for arteriosclerosis of bone vessels and reduced perfusion; and/or 3) direct action of bone cells (osteoblasts/osteocytes) on vascular biology and structure. Inflammation and accumulation of reactive oxygen species are the principal common pathways linking bone and arterial pathologies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bone Diseases, Metabolic / epidemiology
  • Bone Diseases, Metabolic / metabolism*
  • Bone Diseases, Metabolic / pathology
  • Bone Remodeling*
  • Bone and Bones / blood supply
  • Bone and Bones / metabolism*
  • Bone and Bones / pathology
  • Cardiovascular Diseases / epidemiology
  • Cardiovascular Diseases / metabolism*
  • Cardiovascular Diseases / pathology
  • Cell Communication
  • Humans
  • Kidney Failure, Chronic / epidemiology
  • Kidney Failure, Chronic / metabolism
  • Renal Insufficiency, Chronic / epidemiology
  • Renal Insufficiency, Chronic / metabolism*
  • Renal Insufficiency, Chronic / pathology
  • Risk Factors
  • Signal Transduction
  • Vascular Calcification / epidemiology
  • Vascular Calcification / metabolism*
  • Vascular Calcification / pathology