Imaging the interaction: epileptic discharges, working memory, and behavior

Hum Brain Mapp. 2013 Nov;34(11):2910-7. doi: 10.1002/hbm.22115. Epub 2012 Jun 19.


Interictal generalized epileptiform discharges may impair cognition. We used simultaneous video-electroencephalography and functional imaging to quantify changes, induced by epileptiform discharges, in the task-related activations during a spatial working-memory paradigm. The number of epileptiform discharges increased during the task with its level of complexity, but were not significantly associated with wrong responses during the task. We observed hemodynamic responses in working-memory related frontal-lobe-network, motor-cortex, precuneus, and parietal lobes in the absence of epileptiform discharges. In the presence of epileptiform discharges during the task, task-related hemodynamic changes were seen only in motor-cortex, precuneus, and parietal lobes. These findings suggest that generalized epileptiform discharges during a high demanding working memory task may change the working memory-related hemodynamic responses in frontal-lobe-network.

Keywords: IED; behavior; working memory.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Behavior / physiology*
  • Brain Mapping
  • Cerebrovascular Circulation / physiology
  • Confidence Intervals
  • Echo-Planar Imaging
  • Electroencephalography
  • Epilepsy / pathology*
  • Epilepsy / psychology
  • Epilepsy, Generalized / pathology
  • Epilepsy, Generalized / psychology
  • Female
  • Frontal Lobe / blood supply
  • Frontal Lobe / pathology
  • Hemodynamics / physiology
  • Humans
  • Image Processing, Computer-Assisted
  • Memory, Short-Term / physiology*
  • Motor Cortex / blood supply
  • Motor Cortex / pathology
  • Nerve Net / blood supply
  • Nerve Net / pathology
  • Oxygen / blood
  • Parietal Lobe / blood supply
  • Parietal Lobe / pathology
  • Psychomotor Performance / physiology
  • Seizures / pathology
  • Seizures / psychology


  • Oxygen