[The role of matrix metalloproteinases in pancreatic ductal adenocarcinoma]

S E Tsyganov; O V Paklina; G R Setdikova; A V Shabunin; V V Bedin; M M Tavobilov; P N Nikitin

[The role of matrix metalloproteinases in pancreatic ductal adenocarcinoma]

Arkh Patol. 2012 Jan-Feb;74(1):16-8.

[Article in Russian]

Authors

S E Tsyganov, O V Paklina, G R Setdikova, A V Shabunin, V V Bedin, M M Tavobilov, P N Nikitin

PMID: 22712298

Abstract

Matrix metalloproteinases-7, -9 (MMP) are crucial factors for prognosis of pancreatic ductal adenocarcinoma (PDA). The expressions of MMP-2, 7, 9 increased in 60 patients with PDA and depended from stage of disease. Metastasis and invasive growth of tumor correlated with increase of MMP production and decrease of MMP inhibitors' expression, stimulated invasive growth of tumor.

Publication types

English Abstract

MeSH terms

Adult
Aged
Aged, 80 and over
Carcinoma, Pancreatic Ductal / enzymology*
Carcinoma, Pancreatic Ductal / pathology
Collagenases / biosynthesis*
Female
Gene Expression Regulation, Enzymologic*
Gene Expression Regulation, Neoplastic*
Humans
Male
Middle Aged
Neoplasm Invasiveness
Neoplasm Metastasis
Neoplasm Proteins / biosynthesis*
Pancreatic Neoplasms / enzymology*
Pancreatic Neoplasms / pathology

Substances

Neoplasm Proteins
Collagenases