IRGM gene polymorphisms and risk of gastric cancer

J Dig Dis. 2012 Jul;13(7):360-5. doi: 10.1111/j.1751-2980.2012.00602.x.

Abstract

Objective: The study aimed to assess the possible association of polymorphisms in the autophagy gene IRGM (rs13361189 and rs4958847) with the risk of gastric cancer.

Methods: A total of 102 patients with gastric adenocarcinoma, 52 with chronic gastritis and 351 healthy controls were included in this study. IRGM allelic variants were genotyped by quantitative real-time polymerase chain reaction. The association between polymorphisms and gastric cancer risk was estimated by odds ratios (OR) and 95% confidence interval (CI).

Results: A significant difference was found for rs4958847 A allele. Carriers of the A allele were protected against gastric cancer (OR = 0.58, 95% CI 0.35-0.97, P = 0.038). Moreover, the presence of this allele seems to play an important role in decreasing the risk for the intestinal type of gastric cancer (OR = 0.47, 95% CI 0.23-0.94, P = 0.03). In contrast, the rs13361189 IRGM polymorphism was not associated with susceptibility to gastric cancer. None of the targeted polymorphisms were associated with chronic gastritis.

Conclusion: IRGM rs4958847 polymorphism influences susceptibility to gastric cancer, mainly for the intestinal type.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / genetics*
  • Adenocarcinoma / pathology
  • Aged
  • Autophagy / genetics
  • Case-Control Studies
  • Chronic Disease
  • Female
  • GTP-Binding Proteins / genetics*
  • Gastritis / genetics
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Proteins / genetics
  • Polymorphism, Single Nucleotide*
  • Stomach Neoplasms / genetics*
  • Stomach Neoplasms / pathology

Substances

  • Neoplasm Proteins
  • GTP-Binding Proteins
  • IRGM protein, human