Long-term survival after treatment for Hodgkin's disease (1973-2002): improved survival with successive 10-year cohorts

Br J Cancer. 2012 Jul 24;107(3):531-6. doi: 10.1038/bjc.2012.228. Epub 2012 Jun 19.


Background: The Nottinghamshire Lymphoma Registry contains the details of all the patients diagnosed with lymphoma (since 1 January 1973) within a defined geographical area with a population of 1.1 million. It was therefore possible to study the outcome of treatment for Hodgkin's disease for three 10-year cohorts (1973-1982, 1983-1992 and 1993-2002).The aims of the study were to compare survival time among the three patient cohorts, to identify prognostic factors and to estimate relative survival.

Methods: A total of 745 patients diagnosed between 1973 and 2002 were analysed for survival. Survivorship was estimated by the Kaplan-Meier method and parametric survival models. An accelerated failure-time regression was used for multivariate analysis.

Results: Overall, patients were observed for 9.8 (0.3-34.82) years (median(range)), on average. One, five and fifteen-year disease-specific survival was found to be 87% (85-90%), 77% (74-80%) and 70% (67-74%), respectively. For those for diagnosed between 1973 and 1982, the 15-year survival was found to be 57%; for 1983-1992, it was 74% and for 1993-2002, it was 83% (P<0.001). The difference remained significant after adjusting for prognostic factors. The actuarial risk of developing a second malignancy at 20 years was for the 1973-1982 cohort, 12.4%, and for the 1983-1992 cohort, 18.8%.

Conclusion: Treatment advances and effective management of toxicities of treatment over time, have resulted in a significantly longer survival for patients with Hodgkin's disease diagnosed within a defined population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Cohort Studies
  • Female
  • Hodgkin Disease / drug therapy
  • Hodgkin Disease / mortality*
  • Humans
  • Male
  • Middle Aged
  • Neoplasms, Second Primary / drug therapy
  • Neoplasms, Second Primary / epidemiology
  • Neoplasms, Second Primary / mortality
  • Prognosis
  • Survival Rate
  • Survivors / statistics & numerical data*
  • United Kingdom / epidemiology