Confinement loss of inhibited coupling fibers with a cladding composed of a lattice of tubes of various shapes is theoretically and numerically investigated. Both solid core and hollow core are taken into account. It is shown that in case of polygonal shaped tubes, confinement loss is affected by extra loss due to Fano resonances between core modes and cladding modes with high spatial dependence. This explains why hollow core Kagome fibers exhibit much higher confinement loss with respect to tube lattice fibers and why hypocycloid core cladding interfaces significantly reduce fiber loss. Moreover it is shown that tube deformations, due for example to fabrication process, affect fiber performances. A relationship between the number of polygon sides and the spectral position of the extra loss is found. This suggests general guide lines for the design and fabrication of fibers free of Fano resonance in the spectral range of interest.