Mosaic hydrogels: one-step formation of multiscale soft materials

Adv Mater. 2012 Jul 17;24(27):3650-8. doi: 10.1002/adma.201201442. Epub 2012 Jun 20.


The one-step, continuous formation of mosaic hydrogel sheets is presented. A microfluidic device allows controllable incorporation of secondary biopolymers within a flowing biopolymer sheet followed by a cross-linking step that retains the microscale composition. Information is encoded; mosaic stiffness and diffusivity patterns are created; tessellations are populated with biomolecules, microparticles and viable primary cells; and 3D soft material assemblies are demonstrated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alginates / chemistry
  • Biopolymers / chemistry
  • Human Umbilical Vein Endothelial Cells
  • Humans
  • Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry*
  • Microfluidic Analytical Techniques
  • Oligopeptides / chemistry


  • Alginates
  • Biopolymers
  • Oligopeptides
  • Hydrogel, Polyethylene Glycol Dimethacrylate
  • arginyl-glycyl-aspartyl-serine