Lack of association of TLR4 polymorphisms with susceptibility to rheumatoid arthritis and ankylosing spondylitis: a meta-analysis

Joint Bone Spine. 2012 Dec;79(6):566-9. doi: 10.1016/j.jbspin.2012.02.012. Epub 2012 Jun 18.

Abstract

Objective: The aim of the study was to determine whether polymorphisms of toll-like receptor 4 (TLR4) confer susceptibility to rheumatoid arthritis (RA) and ankylosing spondylitis (AS).

Methods: A meta-analysis was conducted on the association between the D299G/T399I polymorphisms and RA/AS (when available) using (1) the allelic contrast, (2) the recessive, (3) the dominant, and (4) the additive models.

Results: A total of eleven relevant studies met the inclusion criteria were identified, including RA: D299G (six studies), T399I (three studies); AS: D299G (five studies), T399I (four studies). Meta-analysis was performed with fixed/random effect models. Overall, no significant RA/AS risk was found in all genetic models when all studies were pooled into the meta-analysis (P>0.05).

Conclusions: The present study might suggest that TLR4 D299G/T399I polymorphisms are not associated with RA/AS susceptibility.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alleles
  • Arthritis, Rheumatoid / genetics*
  • Genetic Predisposition to Disease / genetics*
  • Genotype
  • Humans
  • Polymorphism, Genetic / genetics*
  • Spondylitis, Ankylosing / genetics*
  • Toll-Like Receptor 4 / genetics*

Substances

  • TLR4 protein, human
  • Toll-Like Receptor 4