Pharmacokinetic interactions of selective serotonin reuptake inhibitors with other commonly prescribed drugs in the era of pharmacogenomics

Drug Metabol Drug Interact. 2012 Feb 29;27(1):19-31. doi: 10.1515/dmdi-2011-0033.


Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed to treat depression and a broad range of other comorbidities. The increased use of SSRIs in patients with various comorbidities treated with different drugs engenders the risk of pharmacokinetic drug interactions via cytochrome P450 (CYP450) enzymes inhibition. In the present review, we provide an overview of documented clinically significant drug interactions between SSRIs and other drugs co-prescribed in psychiatric patients for the same or other diseases. We further discuss the significance of drug interactions in the era of pharmacogenomics to underline the need for using information on both genotype and drug interactions towards implementing better clinical outcomes through personalized medicine.

Publication types

  • Review

MeSH terms

  • Animals
  • Cytochrome P-450 Enzyme System / genetics
  • Drug Interactions
  • Drug-Related Side Effects and Adverse Reactions
  • Humans
  • Mental Disorders / drug therapy
  • Polymorphism, Genetic
  • Precision Medicine
  • Serotonin Uptake Inhibitors / pharmacokinetics*
  • Serotonin Uptake Inhibitors / pharmacology
  • Smoking


  • Serotonin Uptake Inhibitors
  • Cytochrome P-450 Enzyme System