Delayed wallerian degeneration in sciatic nerves of C57BL/Ola mice is associated with impaired regeneration of sensory axons

Brain Res. 1990 Oct 15;530(1):117-20. doi: 10.1016/0006-8993(90)90666-y.


Wallerian degeneration is delayed following sciatic nerve crush in C57BL/Ola mice. Compared to C57BL/6J mice, regeneration of sensory axons is significantly slowed in the Ola mice, but reinnervation does eventually occur. We conclude that Wallerian degeneration is a prerequisite for normal sensory axon regeneration following a crush injury to peripheral nerve.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Axons / physiology*
  • Mice
  • Mice, Inbred C57BL
  • Nerve Crush
  • Nerve Regeneration / physiology*
  • Neurons, Afferent / physiology*
  • Sciatic Nerve / physiology*
  • Species Specificity
  • Wallerian Degeneration / physiology*