Non-replication of an association of Apolipoprotein E2 with sinistrality

Laterality. 2013;18(2):251-61. doi: 10.1080/1357650X.2012.660164. Epub 2012 Jun 21.


A recent report found that left-handed adolescents were more than three times more likely to have an Apolipoprotein (APOE) ϵ2 allele. This study was unable to replicate this association in young adults (N=166). A meta-analysis of nine other datasets (N=360 to 7559, Power > 0.999) including that of National Alzheimer's Coordinating Center also failed to find an over-representation of ϵ2 among left-handers indicating that this earlier outcome was most likely a statistical artefact.

Publication types

  • Meta-Analysis
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Alleles*
  • Apolipoproteins E / genetics*
  • Female
  • Functional Laterality / genetics*
  • Genetic Association Studies
  • Genotype
  • Humans
  • Male
  • Young Adult


  • Apolipoproteins E