Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Apr 10;368(1-2):1-16.
doi: 10.1016/j.mce.2012.06.007. Epub 2012 Jun 19.

Regulation of Cholesterol Homeostasis

Affiliations
Review

Regulation of Cholesterol Homeostasis

Mariëtte Y M van der Wulp et al. Mol Cell Endocrinol. .

Abstract

Hypercholesterolemia is an important risk factor for cardiovascular disease. It is caused by a disturbed balance between cholesterol secretion into the blood versus uptake. The pathways involved are regulated via a complex interplay of enzymes, transport proteins, transcription factors and non-coding RNA's. The last two decades insight into underlying mechanisms has increased vastly but there are still a lot of unknowns, particularly regarding intracellular cholesterol transport. After decades of concentration on the liver, in recent years the intestine has come into focus as an important control point in cholesterol homeostasis. This review will discuss current knowledge of cholesterol physiology, with emphasis on cholesterol absorption, cholesterol synthesis and fecal excretion, and new (possible) therapeutic options for hypercholesterolemia.

Similar articles

See all similar articles

Cited by 35 articles

See all "Cited by" articles

Publication types

LinkOut - more resources

Feedback