Rebleeding after aneurysmal subarachnoid hemorrhage: a literature review

World Neurosurg. 2013 Feb;79(2):307-12. doi: 10.1016/j.wneu.2012.06.023. Epub 2012 Jun 19.


Objective: To summarize the current knowledge of the mechanisms leading to rebleeding and the prevention of rebleeding after subarachnoid hemorrhage (SAH).

Methods: A literature search was performed to investigate factors associated with rebleeding after SAH.

Results: The review of the literature revealed that rebleeding is a complex and multifactorial event involving hemostasis, pathophysiologic, and anatomic factors. Administration of antifibrinolytics has been shown to have a dramatic effect on the rebleeding rate, so changes in coagulation and fibrinolysis must be involved in rebleeding.

Conclusions: Further studies are warranted before the exact mechanisms leading to rebleeding are established and the optimal preventive measures are made available. At the present time, antifibrinolytic therapy remains the only realistic protective measure during the initial 6 hours after SAH during which the rebleeding rate is highest.

Publication types

  • Review

MeSH terms

  • Antifibrinolytic Agents / therapeutic use
  • Cerebrospinal Fluid Pressure
  • Hemostasis
  • Humans
  • Risk Factors
  • Secondary Prevention
  • Subarachnoid Hemorrhage / etiology*
  • Subarachnoid Hemorrhage / physiopathology*
  • Subarachnoid Hemorrhage / therapy


  • Antifibrinolytic Agents