Non-peptide angiotensin II receptor antagonists discriminate subtypes of 125I-angiotensin II binding sites in the rat brain

Eur J Pharmacol. 1990 Oct 2;187(1):123-6. doi: 10.1016/0014-2999(90)90348-a.

Abstract

We have utilized quantitative autoradiography to define subtypes of 125I-angiotensin II (AII) binding in rat brain. AII-1 binding (displaced by DuP 753) was found in the nucleus of the solitary tract and the hypothalamus, while AII-2 binding (displaced by WL 19) was found in the thalamus and lateral septum. These results indicate that subtypes of the AII receptor are present in the brain and the AII-1 receptor subtype is present in regions consistant with the known actions of angiotensin.

MeSH terms

  • Angiotensin II / antagonists & inhibitors
  • Angiotensin II / metabolism*
  • Angiotensin Receptor Antagonists
  • Animals
  • Autoradiography
  • Binding, Competitive / drug effects
  • Brain / anatomy & histology
  • Brain Chemistry / drug effects
  • Hypothalamus / anatomy & histology
  • Hypothalamus / metabolism
  • Imidazoles / pharmacology
  • Iodine Radioisotopes
  • Losartan
  • Male
  • Medulla Oblongata / anatomy & histology
  • Medulla Oblongata / metabolism
  • Pyridines / pharmacology
  • Rats
  • Rats, Inbred Strains
  • Receptors, Angiotensin / drug effects*
  • Tetrazoles / pharmacology

Substances

  • Angiotensin Receptor Antagonists
  • Imidazoles
  • Iodine Radioisotopes
  • Pyridines
  • Receptors, Angiotensin
  • Tetrazoles
  • Angiotensin II
  • WL 19
  • Losartan