Sudden loss of milk supply following high-dose triamcinolone (Kenacort) injection

Breastfeed Rev. 2012 Mar;20(1):32-4.


Endogenous corticosteroids are involved in breast development, initiation and maintenance of milk production. Animal studies have shown that exogenous corticosteroids diminish milk production and milk ejection. A high dose depot injection of triamcinolone resulted in dramatic reduction in milk production in an established lactation. Domperidone and frequent expression restored milk production. Lower dose depot injection of betamethasone into the shoulder joint did not noticeably reduce milk production.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Dose-Response Relationship, Drug
  • Female
  • Glucocorticoids / administration & dosage
  • Glucocorticoids / adverse effects*
  • Humans
  • Infant, Newborn
  • Lactation / drug effects*
  • Lactation Disorders / chemically induced*
  • Lactation Disorders / prevention & control
  • Maternal Behavior / drug effects
  • Milk Ejection / drug effects
  • Neurosecretory Systems / drug effects*
  • Sensation Disorders / drug therapy
  • Triamcinolone Acetonide / administration & dosage*
  • Triamcinolone Acetonide / adverse effects*


  • Glucocorticoids
  • Triamcinolone Acetonide