Pregabalin in clinical psychiatry and addiction: pros and cons

Expert Opin Investig Drugs. 2012 Sep;21(9):1243-5. doi: 10.1517/13543784.2012.703179. Epub 2012 Jun 24.

Abstract

Pregabalin acts as a presynaptic modulator of excitatory neurotransmitter release, binding to the α²-δ subunit protein of voltage-gated calcium channels. Pregabalin use is becoming widespread in the psychiatric scenario. Data are encouraging, with some good evidence for efficacy in anxious spectrum, benzodiazepine abuse/dependence, and alcoholism. The abuse potential, however, is an issue that should be taken into account, mostly in subjects at risk for developing substance/alcohol misuse.

Publication types

  • Editorial

MeSH terms

  • Alcoholism / drug therapy
  • Anticonvulsants / adverse effects
  • Anticonvulsants / therapeutic use
  • Anxiety Disorders / drug therapy*
  • Benzodiazepines / adverse effects
  • Calcium Channels / drug effects
  • Calcium Channels / metabolism
  • Humans
  • Pregabalin
  • Substance-Related Disorders / drug therapy*
  • gamma-Aminobutyric Acid / adverse effects
  • gamma-Aminobutyric Acid / analogs & derivatives*
  • gamma-Aminobutyric Acid / therapeutic use

Substances

  • Anticonvulsants
  • Calcium Channels
  • Benzodiazepines
  • Pregabalin
  • gamma-Aminobutyric Acid