Perifollicular fibroma in Birt-Hogg-Dubé syndrome: an association revisited

J Cutan Pathol. 2012 Jul;39(7):675-9. doi: 10.1111/j.1600-0560.2012.01929.x.


Background: Mutation in the folliculin gene in Birt-Hogg-Dubé (BHD) syndrome leads to a spectrum of benign tumors of the hair follicle, classically including both fibrofolliculoma and trichodiscoma. In addition, lesions clinically indistinguishable from fibrofolliculoma/ trichodiscoma may show histopathologic findings of perifollicular fibroma or angiofibroma. Although some consider perifollicular fibroma to be a variant of angiofibroma, the specific histopathologic findings of perifollicular fibroma are uncommon.

Methods: This is a case series.

Results: In 4 patients with multiple facial lesions, recognizing perifollicular fibroma would have been helpful in leading to the diagnosis of BHD syndrome.

Conclusion: Perifollicular fibroma is on a spectrum with fibrofolliculoma and trichodiscoma; in a patient with multiple lesions, the diagnosis of perifollicular fibroma is suggestive of BHD syndrome.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Birt-Hogg-Dube Syndrome / pathology*
  • Facial Neoplasms / pathology*
  • Fibroma / pathology*
  • Humans
  • Male
  • Middle Aged
  • Skin Neoplasms / pathology*