Therapeutic potential of Lactobacillus plantarum CJLP133 for house-dust mite-induced dermatitis in NC/Nga mice

Cell Immunol. 2012 May-Jun;277(1-2):49-57. doi: 10.1016/j.cellimm.2012.05.013. Epub 2012 Jun 5.


Lactobacillus plantarum CJLP133 was isolated from Kimchi, a Korean fermented food, and its potential to improve mouse atopic dermatitis after onset was studied. Dermatitis was developed through house dust-mite extract application onto NC/Nga mice, and then CJLP133 feeding was started. CJLP133 suppressed dermatitis-like skin lesions and decreased high serum IgE levels through balancing between IL-4 and IFN-γ in serum. CJLP133 diminished skin thickening, mast cell accumulation into inflamed site, and lymph node enlargement. In lymph node cells, CJLP133 repressed secretion of T cell cytokines such as IFN-γ, IL-4, IL-5, and IL-10. However, CJLP133 decreased ratios of IFN-γ and IL-5 to IL-10 in lymph node cells, while it did not decrease ratios of IL-4 and IL-5 to IFN-γ. Conclusively, CJLP133 exhibited therapeutic potential for atopic dermatitis in mice through orderly increment of type 1 helper T cell activation and regulatory T cell activation. These results suggest that CJLP133 could treat human atopic dermatitis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cytokines / metabolism
  • Dermatitis, Allergic Contact / microbiology*
  • Dermatitis, Allergic Contact / pathology
  • Dermatitis, Allergic Contact / therapy*
  • Immunoglobulin E / blood
  • Interferon-gamma / blood
  • Interleukin-4 / blood
  • Lactobacillus plantarum*
  • Lymph Nodes / metabolism
  • Lymph Nodes / pathology
  • Mast Cells / pathology
  • Mice
  • Pyroglyphidae / immunology*
  • T-Lymphocytes, Helper-Inducer / pathology
  • T-Lymphocytes, Regulatory / pathology


  • Cytokines
  • Interleukin-4
  • Immunoglobulin E
  • Interferon-gamma