Rewriting the epigenome

Benjamin R Carone; Oliver J Rando

doi:10.1016/j.cell.2012.06.008

Rewriting the epigenome

Cell. 2012 Jun 22;149(7):1422-3. doi: 10.1016/j.cell.2012.06.008.

Authors

Benjamin R Carone¹, Oliver J Rando

Affiliation

¹ Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA. benjamin.carone@umassmed.edu

PMID: 22726428
DOI: 10.1016/j.cell.2012.06.008

Abstract

The eukaryotic genome is packaged into a highly ordered chromatin structure, with specific domains regulating the transcription patterns of local genes. Hathaway et al. now present a breakthrough technique in the artificial induction of chromatin marks and use this experimental model to test the properties of an induced heterochromatic domain.

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