Membrane protein structure predictions for exploration

Cell. 2012 Jun 22;149(7):1424-5. doi: 10.1016/j.cell.2012.06.004.


A daring experiment is performed. Using sequence alignments to predict contacts between residues in protein spatial structures, Hopf et al. are publishing untested de novo structure models for 11 transmembrane protein families. Will their models stand the test of time and hold up to experimentation? The prospects are excellent.

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