Tiki casts a spell on Wnt

Cell. 2012 Jun 22;149(7):1426-7. doi: 10.1016/j.cell.2012.06.007.


Negative feedback is a widespread feature of signaling pathways. In an unexpected twist described in this issue, He and colleagues identify a membrane-tethered metalloprotease named Tiki that inhibits Wnt signaling by removing an essential eight-residue fragment from Wnt itself.

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