A movie of RNA polymerase II transcription

Cell. 2012 Jun 22;149(7):1431-7. doi: 10.1016/j.cell.2012.06.006.


We provide here a molecular movie that captures key aspects of RNA polymerase II initiation and elongation. To create the movie, we combined structural snapshots of the initiation-elongation transition and of elongation, including nucleotide addition, translocation, pausing, proofreading, backtracking, arrest, reactivation, and inhibition. The movie reveals open questions about the mechanism of transcription and provides a useful teaching tool.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Archaea / enzymology
  • Archaea / metabolism
  • Bacteria / enzymology
  • Bacteria / metabolism
  • Fungi / enzymology
  • Fungi / metabolism
  • Humans
  • Motion Pictures
  • RNA Polymerase II / chemistry
  • RNA Polymerase II / metabolism*
  • Transcription Factors / chemistry
  • Transcription Factors / metabolism
  • Transcription, Genetic*


  • Transcription Factors
  • RNA Polymerase II