The role of proton MR spectroscopy and apparent diffusion coefficient values in the diagnosis of malignant thyroid nodules: preliminary results

Clin Imaging. Jul-Aug 2012;36(4):323-33. doi: 10.1016/j.clinimag.2011.09.009. Epub 2012 Jun 8.

Abstract

Purpose: Performance of proton magnetic resonance spectroscopy (H-MRS) and apparent diffusion coefficient (ADC) values in the diagnosis of malignant thyroid nodules.

Method: In a retrospective study with malignant nodules of 14 patients, H-MRS and diffusion-weighted MR imaging (DWI) were performed. Choline (Cho) peak, Cho/creatine (Cr) ratio, and ADC values of malignant nodules were correlated with the five benign nodules and four normal-appearing thyroid lobe parenchymata. The gold standard reference was fine needle aspiration biopsy and histopathology.

Results: At echo time 40-144-ms acquisitions, average Cho/Cr ratio for the malignant nodules was 2.95±1.54-5.30±2.38, cutoff values were >0.805 and >1.225, and ADC values were 0.06±0.02.

Conclusion: H-MRS acquisitions, DWI, and ADC mapping give diagnostic data about the nature of the nodules.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Biopsy, Fine-Needle
  • Cohort Studies
  • Diffusion Magnetic Resonance Imaging / methods*
  • Female
  • Humans
  • Image Interpretation, Computer-Assisted*
  • Immunohistochemistry
  • Magnetic Resonance Spectroscopy / methods*
  • Male
  • Middle Aged
  • Neoplasm Invasiveness / pathology
  • Neoplasm Staging
  • ROC Curve
  • Reproducibility of Results
  • Retrospective Studies
  • Sensitivity and Specificity
  • Thyroid Neoplasms / diagnosis
  • Thyroid Neoplasms / pathology
  • Thyroid Nodule / diagnosis*
  • Thyroid Nodule / pathology