1. Adamson C.S., Freed E.O. Novel approaches to inhibiting HIV-1 replication. Antiviral Res. 2010;85:119–141. doi: 10.1016/j.antiviral.2009.09.009. - DOI - PMC - PubMed
    1. Cos P., Maes L., Vanden Berghe D., Hermans N., Pieters L., Vlietinck A. Plant substances as anti-HIV agents selected according to their putative mechanism of action. J. Nat. Prod. 2004;67:284–293. doi: 10.1021/np034016p. - DOI - PubMed
    1. de Clercq E. Current lead natural products for the chemotherapy of human immunodeficiency virus (HIV) infection. Med. Res. Rev. 2000;20:323–349. doi: 10.1002/1098-1128(200009)20:5<323::AID-MED1>3.0.CO;2-A. - DOI - PubMed
    1. Zhang X., Huang N., Zheng Y.T. Advances in the study of anti-HIV natural compounds derived from traditional Chinese medicines (in Chinese) Acta Pharm. Sin. 2010;45:141–153. - PubMed
    1. Sakagami H., Kawazoe Y., Komatsu N., Simpson A., Nonoyama M., Konno K., Yoshida T., Kuroiwa Y., Tanuma S. Antitumor, antiviral and immunopotentiating activities of pine cone extracts: Potential medicinal efficacy of natural and synthetic lignin-related materials (review) Anticancer Res. 1991;11:881–888. - PubMed
    1. Lai P.K., Donovan J., Takayama H., Sakagami H., Tanaka A., Konno K., Nonoyama M. Modification of human immunodeficiency viral replication by pine cone extracts. AIDS Res. Hum. Retroviruses. 1990;6:205–217. doi: 10.1089/aid.1990.6.205. - DOI - PubMed
    1. Tamura Y., Lai P.K., Bradley W.G., Konno K., Tanaka A., Nonoyama M. A soluble factor induced by an extract from Pinus parviflora Sieb et Zucc can inhibit the replication of human-immunodeficiency-virus in vitro. Proc. Natl. Acad. Sci. USA. 1991;88:2249–2253. doi: 10.1073/pnas.88.6.2249. - DOI - PMC - PubMed
    1. Eberhardt T.L., Young R.A. Assessment of the anti-HIV activity of a pine cone isolate. Planta Med. 1996;62:63–65. doi: 10.1055/s-2006-957801. - DOI - PubMed
    1. Satoh K., Kihara T., Ida Y., Sakagami H., Koyama N., Premanathan M., Arakaki R., Nakashima H., Komatsu N., Fujimaki M., et al. Radical modulation activity of pine cone extracts of Pinus elliottii var. Elliottii. Anticancer Res. 1999;19:357–364. - PubMed
    1. Li N., Fu L.K. Notes on gymnosperms. 1. Taxonomic treatments of some Chinese conifers. Novon. 1997;7:261–264. doi: 10.2307/3391941. - DOI
    1. Young R.C., Friedman M.A., Schilsky R.L., Sigal E.V. Drug safety and drug efficacy: Two sides of the same coin. Clin. Cancer Res. 2007;13:2533–2534. doi: 10.1158/1078-0432.CCR-07-0608. - DOI - PubMed
    1. Este J.A. Virus entry as a target for anti-HIV intervention. Curr. Med. Chem. 2003;10:1617–1632. doi: 10.2174/0929867033457098. - DOI - PubMed
    1. Garcia-Sosa A.T., Sild S., Takkis K., Maran U. Combined approach using ligand efficiency, cross-docking, and antitarget hits for wild-type and drug-resistant Y181C HIV-1 reverse transcriptase. J. Chem. Inf. Model. 2011;51:2595–2611. doi: 10.1021/ci200203h. - DOI - PubMed
    1. Cichero E., Fossa P. Docking-based 3D-QSAR analyses of pyrazole derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors. J. Mol. Model. 2012;18:1573–1582. doi: 10.1007/s00894-011-1190-5. - DOI - PubMed
    1. Mao Y., Li Y., Hao M., Zhang S., Ai C. Docking, molecular dynamics and quantitative structure-activity relationship studies for HEPTs and DABOs as HIV-1 reverse transcriptase inhibitors. J. Mol. Model. 2012;18:2185–2198. doi: 10.1007/s00894-011-1236-8. - DOI - PubMed
    1. Sakagami H., Kushida T., Oizumi T., Nakashima H., Makino T. Distribution of lignin-carbohydrate complex in plant kingdom and its functionality as alternative medicine. Pharmacol. Ther. 2010;128:91–105. doi: 10.1016/j.pharmthera.2010.05.004. - DOI - PubMed
    1. Zhou P., Lin F., Liu J., Lv Y.J., Li H.Z., Liu G.M. Determination of carbohydrate content in lignin-carbohydrate complex from pine cone of Pinus yunnanensis Franch (in Chinese) Lishizhen Med. Mater Med. Res. 2011;22:1820–1821.
    1. Lesbats P., Botbol Y., Chevereau G., Vaillant C., Calmels C., Arneodo A., Andreola M.L., Lavigne M., Parissi V. Functional coupling between HIV-1 Integrase and the SWI/SNF Chromatin remodeling complex for efficient in vitro integration into stable nucleosomes. PLoS Pathog. 2011;7:e1001280. doi: 10.1371/journal.ppat.1001280. - DOI - PMC - PubMed
    1. Esposito D., Craigie R. HIV integrase structure and function. Adv. Virus Res. 1999;52:319–333. doi: 10.1016/S0065-3527(08)60304-8. - DOI - PubMed
    1. van Maele B., Debyser Z. HIV-1 integrated: An interplay between HIV-1 integrase, cellular and cellular and viral. AIDS Rev. 2005;7:26–43. - PubMed
    1. Maertens G., Cherepanov P., Pluymers W., Busschots K., de Clercq E., Debyser Z., Engelborghs Y. LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells. J. Biol. Chem. 2003;278:33528–33539. - PubMed
    1. Levin A., Hayouka Z., Friedler A., Loyter A. Transportin 3 and importin alpha are required for effective nuclear import of HIV-1 integrase in virus-infected cells. Nucleus. 2010;1:422–431. - PMC - PubMed
    1. Levin A., Armon-Omer A., Rosenbluh J., Melamed-Book N., Graessmann A., Waigmann E., Loyter A. Inhibition of HIV-1 integrase nuclear import and replication by a peptide bearing integrase putative nuclear localization signal. Retrovirology. 2009;6:112. doi: 10.1186/1742-4690-6-112. - DOI - PMC - PubMed
    1. Du L., Chen J., Yang L.M., Zheng Y.T., Tang Y., Shen X., Jiang H.L. D77, one benzoic acid derivative, functions as a novel anti-HIV-1 inhibitor targeting the interaction between integrase and cellular LEDGF/p75. Biochem. Biophys. Res. Commun. 2008;375:139–144. doi: 10.1016/j.bbrc.2008.07.139. - DOI - PubMed
    1. Murakami T., Yamamoto N. Role of CXCR4 in HIV infection and its potential as a therapeutic target. Future Microbiol. 2010;5:1025–1039. doi: 10.2217/fmb.10.67. - DOI - PubMed
    1. Dong C.Z., Tian S., Madani N., Choi W.T., Kumar S., Liu D., Sodroski J.G., Huang Z., An J. Role of CXCR4 internalization in the anti-HIV activity of stromal cell-derived factor-1alpha probed by a novel synthetically and modularly modified-chemokine analog. Exp. Biol. Med. (Maywood) 2011;236:1413–1419. - PMC - PubMed
    1. Liu G.J., Wang J.P., Xiao J.C., Zhao Z.W., Zheng Y.T. Preparation and characterization of three monoclonal antibodies against HIV-1 p24 capsid protein. Cell. Mol. Immunol. 2007;4:203–208. - PubMed
    1. Wang R.R., Gu Q.O., Yang L.M., Chen J.J., Li S.Y., Zheng Y.T. Anti-HIV-1 activities of extracts from the medicinal plant Rhus chinensis. J. Ethnopharmacol. 2006;105:269–273. doi: 10.1016/j.jep.2005.11.008. - DOI - PubMed
    1. Wang R.R., Gu Q., Wang Y.H., Zhang X.M., Yang L.M., Zhou J., Chen J.J., Zheng Y.T. Anti-HIV-1 activities of compounds isolated from the medicinal plant Rhus chinensis. J. Ethnopharmacol. 2008;117:249–256. doi: 10.1016/j.jep.2008.01.037. - DOI - PubMed
    1. Zhang X.J., Yang G.Y., Wang R.R., Pu J.X., Sun H.D., Xiao W.L., Zheng Y.T. 7,8-Secolignans from Schisandra wilsoniana and Their anti-HIV-1 activities. Chem. Biodivers. 2010;7:2692–2701. doi: 10.1002/cbdv.200900367. - DOI - PubMed
    1. Xiao W.L., Wang R.R., Zhao W., Tian R.R., Shang S.Z., Yang L.M., Yang J.H., Pu J.X., Zheng Y.T., Sun H.D. Anti-HIV-1 activity of lignans from the fruits of Schisandra rubriflora. Arch. Pharm. Res. 2010;33:697–701. doi: 10.1007/s12272-010-0508-7. - DOI - PubMed
    1. Wang Y.H., Tang J.G., Wang R.R., Yang L.M., Dong Z.J., Du L., Shen X., Liu J.K., Zheng Y.T. Flazinamide, a novel beta-carboline compound with anti-HIV actions. Biochem. Biophys. Res. Commun. 2007;355:1091–1095. doi: 10.1016/j.bbrc.2007.02.081. - DOI - PubMed
    1. Wang Q., Ding Z.H., Liu J.K., Zheng Y.T. Xanthohumol, a novel anti-HIV-1 agent purified from Hops Humulus lupulus. Antiviral Res. 2004;64:189–194. - PubMed