Celiac disease: advances in treatment via gluten modification

Clin Gastroenterol Hepatol. 2012 Aug;10(8):859-62. doi: 10.1016/j.cgh.2012.06.005. Epub 2012 Jun 19.


Celiac disease (CD) is an autoimmune enteropathy that occurs in genetically susceptible individuals carrying the prerequisite genetic markers HLA DQ2 or DQ8. These genetic markers are present in approximately 30% of the population, and the worldwide prevalence of CD is estimated to be approximately 1%-2%. Currently a gluten-free diet is the only treatment for CD, but novel therapies aimed at gluten modification are underway. This review will discuss gluten-based therapies including wheat alternatives and wheat selection, enzymatic alteration of wheat, oral enzyme supplements, and polymeric binders as exciting new therapies for treatment of CD.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Celiac Disease / therapy*
  • Diet, Gluten-Free / methods*
  • Dietary Supplements
  • Enzyme Therapy / methods
  • Glutens / metabolism*
  • Humans


  • Glutens