Antibiotics from basidiomycetes. XXXVII. New inhibitors of cholesterol biosynthesis from cultures of Xerula melanotricha Dörfelt

J Antibiot (Tokyo). 1990 Nov;43(11):1413-20. doi: 10.7164/antibiotics.43.1413.

Abstract

Three new inhibitors of cholesterol biosynthesis have been isolated from cultures of Xerula melanotricha and their structures elucidated by spectroscopic methods. Dihydroxerulin (1) in admixture with xerulin (2) strongly inhibits the incorporation of 14C- acetate into cholesterol in HeLa cells while the incorporation of 14C-mevalonate is not affected. Xerulinic acid (3) shows similar biological activities but a higher cytotoxicity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Agaricales / metabolism*
  • Animals
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology*
  • Anticholesteremic Agents / chemistry
  • Anticholesteremic Agents / isolation & purification
  • Anticholesteremic Agents / pharmacology*
  • Bacteria / drug effects
  • Diynes
  • Fermentation
  • Fungi / drug effects
  • HeLa Cells
  • Humans
  • Lactones / chemistry
  • Lactones / isolation & purification
  • Lactones / pharmacology*
  • Magnetic Resonance Spectroscopy
  • Male
  • Molecular Conformation
  • Molecular Structure
  • Rats
  • Rats, Inbred Strains

Substances

  • Anti-Bacterial Agents
  • Anticholesteremic Agents
  • Diynes
  • Lactones
  • dihydroxerulin
  • xerulin
  • xerulinic acid