Abstract
Optogenetic silencing using light-driven ion fluxes permits rapid and effective inhibition of neural activity. Using rodent hippocampal neurons, we found that silencing activity with a chloride pump can increase the probability of synaptically evoked spiking after photoactivation; this did not occur with a proton pump. This effect can be accounted for by changes to the GABA(A) receptor reversal potential and demonstrates an important difference between silencing strategies.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Hippocampus / cytology
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Hippocampus / physiology*
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Ion Pumps* / metabolism
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Ion Pumps* / radiation effects
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Neural Inhibition / radiation effects*
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Neurons / radiation effects*
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Proton Pumps / metabolism
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Proton Pumps / radiation effects
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Rats
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Receptors, GABA-A* / metabolism
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Receptors, GABA-A* / radiation effects
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Synaptic Transmission* / physiology
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Synaptic Transmission* / radiation effects
Substances
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Ion Pumps
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Proton Pumps
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Receptors, GABA-A