Structure and noncanonical chemistry of nonribosomal peptide biosynthetic machinery

Nat Prod Rep. 2012 Oct;29(10):1099-110. doi: 10.1039/c2np20023f. Epub 2012 Jun 25.

Abstract

Structural biology has provided significant insights into the complex chemistry and macromolecular organization of nonribosomal peptide synthetases. In addition, novel pathways are continually described, expanding the knowledge of known biosynthetic chemistry.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Biological Products / chemistry*
  • Biological Products / isolation & purification
  • Biological Products / metabolism
  • Molecular Structure
  • Peptide Synthases / chemistry*
  • Peptide Synthases / metabolism*
  • Peptides / chemistry*
  • Peptides / metabolism
  • Protein Conformation

Substances

  • Biological Products
  • Peptides
  • Peptide Synthases
  • non-ribosomal peptide synthase