Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2012 Jun 21;2012:bcr0220125878.
doi: 10.1136/bcr.02.2012.5878.

Remission Without Insulin Therapy on Gluten-Free Diet in a 6-year Old Boy With Type 1 Diabetes Mellitus

Affiliations
Free PMC article
Case Reports

Remission Without Insulin Therapy on Gluten-Free Diet in a 6-year Old Boy With Type 1 Diabetes Mellitus

Stine Møller Sildorf et al. BMJ Case Rep. .
Free PMC article

Abstract

A 5-year and 10-month old boy was diagnosed with classical type 1 diabetes mellitus (T1DM) without celiac disease. He started on a gluten-free diet after 2-3 week without need of insulin treatment. At the initiation of gluten-free diet, HbA1c was 7.8% and was stabilised at 5.8%-6.0% without insulin therapy. Fasting blood glucose was maintained at 4.0-5.0 mmol/l. At 16 months after diagnosis the fasting blood glucose was 4.1 mmol/l and after 20 months he is still without daily insulin therapy. There was no alteration in glutamic acid decarboxylase positivity. The gluten-free diet was safe and without side effects. The authors propose that the gluten-free diet has prolonged remission in this patient with T1DM and that further trials are indicated.

Conflict of interest statement

Competing interests: Stine Møller Sildorf: stock ownership at NovoNordisk. Jannet Svensson: stock ownership af NovoNordisk

Figures

Figure 1
Figure 1
(A) Insulin adjusted A1c% in the index patient (in red) and in 21 other diabetic children (matched by age and diabetes duration) aged 4–8 years (in black) against stimulated C-peptide pmol/l. Insulin adjusted A1c ≤9% indicates remission. (B) Insulin requirement mmol/l for the corresponding HbA1c% after 12 months.

Similar articles

See all similar articles

Cited by 22 articles

See all "Cited by" articles

Publication types

Feedback