Inhibition of gastrointestinal lipolysis by green tea, coffee, and gomchui (Ligularia fischeri) tea polyphenols during simulated digestion

J Agric Food Chem. 2012 Jul 25;60(29):7152-7. doi: 10.1021/jf301047f. Epub 2012 Jul 11.


Green tea, coffee, and gomchui (Ligularia fischeri) tea, which are rich in polyphenols, may exhibit antiobesity effects by inhibiting pancreatic lipase. However, the bioavailability of some polyphenols is poor due to either degradation or absorption difficulties in the gastrointestinal tract, thus making their beneficial effects doubtful. This study was conducted to evaluate the inhibitory effect of three beverages on lipolysis and the contribution of their major polyphenols during simulated digestion. During simulated digestion, gomchui tea was the most potent at inhibiting gastrointestinal lipolysis, whereas green tea was the least potent. The strongest lipase inhibitor among purified major polyphenols was a green tea polyphenol, (-)-epigallocatechin gallate (EGCG, IC(50) = 1.8 ± 0.57 μM), followed by di-O-caffeoylquinic acid isomers (DCQA, IC(50) from 12.7 ± 4.5 to 40.4 ± 2.3 μM), which are gomchui tea polyphenols. However, the stability of DCQA was greater than that of EGCG when subjected to simulated digestion. Taken together, gomchui tea, which has DCQA as the major polyphenol, showed stronger lipolysis inhibitory activity during simulated digestion compared to both green tea and coffee.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Obesity Agents / pharmacology
  • Asteraceae / chemistry*
  • Beverages
  • Biological Availability
  • Coffee / chemistry*
  • Digestion*
  • Enzyme Inhibitors / pharmacology
  • Gastrointestinal Tract / enzymology
  • Humans
  • In Vitro Techniques
  • Lipase / antagonists & inhibitors*
  • Lipolysis / drug effects
  • Pancreas / enzymology
  • Polyphenols / pharmacokinetics
  • Polyphenols / pharmacology*
  • Tea / chemistry*


  • Anti-Obesity Agents
  • Coffee
  • Enzyme Inhibitors
  • Polyphenols
  • Tea
  • Lipase