Solid-phase synthesis of γ-AApeptides using a submonomeric approach

Org Lett. 2012 Jul 6;14(13):3446-9. doi: 10.1021/ol301406a. Epub 2012 Jun 25.


The solid-phase synthesis of γ-AApeptides using a novel submonomeric approach that utilizes an allyl protection is reported. The strategy successfully circumvents the necessity of preparing γ-AApeptide building blocks in order to prepare γ-AApeptide sequences. This method will maximize the potential of developing chemically diverse γ-AApeptide libraries and thereby facilitate the biological applications of γ-AApeptides in the future.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Molecular Structure
  • Peptides / chemical synthesis*
  • Peptides / chemistry


  • Peptides