Intracranial mesenchymal chondrosarcoma: case report and literature review

Br J Neurosurg. 2012 Dec;26(6):912-4. doi: 10.3109/02688697.2012.697219. Epub 2012 Jun 25.


Background: Mesenchymal chondrosarcoma is a very rare malignant cartilaginous forming tumour in central nervous system (CNS), which is rarely encountered in clinical practice and generally occurs in young adults. This article describes a case of primary intracranial mesenchymal chondrosarcoma in a 31-year-old woman and reviews the literature on its manifestations and management.

Case report: This patient had suffered from severe headache, intermittent nausea and vomiting for 1 week. Systemic examination was unremarkable. Magnetic resonance imaging (MRI) demonstrated a giant, heterogeneous, intensely enhancing mass of 6 × 5 × 4 cm, occupying the bilateral frontal and based on the anterior falx cerebri, which was initially thought to be a simply meningioma. The patient underwent a bicoronal craniotomy and gross total resection of the tumour. Pathologic examination revealed the mesenchymal chondrosarcoma.

Conclusion: Intracranial mesenchymal chondrosarcoma is an extreme rare neoplasm, which should be considered in the differential diagnosis of intracranial mass like a meningioma. We emphasize the importance of surgical intervention and combination of microsurgical resection and radiotherapy, it should be the therapeutical choice of the future.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Bone Neoplasms* / pathology
  • Bone Neoplasms* / radiotherapy
  • Bone Neoplasms* / surgery
  • Chondrosarcoma, Mesenchymal* / pathology
  • Chondrosarcoma, Mesenchymal* / radiotherapy
  • Chondrosarcoma, Mesenchymal* / surgery
  • Dura Mater* / pathology
  • Dura Mater* / surgery
  • Female
  • Frontal Lobe* / pathology
  • Frontal Lobe* / surgery
  • Humans