Renal functional reserve in children with apparently normal congenital solitary functioning kidney

Clin Biochem. 2012 Oct;45(15):1173-7. doi: 10.1016/j.clinbiochem.2012.06.018. Epub 2012 Jun 23.


Objective: The aim of the study was to investigate renal functional reserve (RFR) and to assess its relationship with serum cystatin C and blood pressure in children with apparently normal congenital solitary functioning kidney (SFK).

Material and methods: RFR was obtained from the difference of endogenous creatinine clearance (CrCs) before and after a meat-free oral protein load (OPL) in the patients who were pre-treated with cimetidine. Serum cystatin C and urinary protein excretion were determined before and after OPL.

Results: Among 22 patients (13 boys), aged 9.5 ± 4.3 years, 72.7% had increased serum cystatin C, and 54.5% had decreased RFR. Following OPL, CrCs and urine creatinine increased, while serum creatinine and cystatin C remained unchanged. The multiple regression analysis demonstrated that cystatin C could predict more than 90% of RFR variability.

Conclusion: Half of the patients with apparently normal SFK had decreased RFR. Serum cystatin C is one of the best predictors of RFR.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Cystatin C / blood
  • Female
  • Glomerular Filtration Rate
  • Humans
  • Kidney / abnormalities*
  • Kidney / pathology
  • Kidney / physiopathology*
  • Kidney Diseases / blood
  • Kidney Diseases / congenital*
  • Kidney Diseases / physiopathology
  • Male
  • Multicystic Dysplastic Kidney / blood
  • Multicystic Dysplastic Kidney / physiopathology
  • Multivariate Analysis
  • Organ Size
  • Regression Analysis


  • Cystatin C