Circulating microRNA is a biomarker of biliary atresia

J Pediatr Gastroenterol Nutr. 2012 Oct;55(4):366-9. doi: 10.1097/MPG.0b013e318264e648.


Objective: The lack of reliable noninvasive diagnostic biomarkers of biliary atresia (BA) results in delayed diagnosis and worsened patient outcome. Circulating microRNAs (miRNAs) are a new class of noninvasive biomarkers with encouraging diagnostic utility.

Methods: We examined the ability of serum miRNAs to distinguish BA from other forms of neonatal hyperbilirubinemia. BA-specific serum miRNAs were identified using a microfluidic array platform and validated in a larger, independent sample set.

Results: The miR-200b/429 cluster was significantly increased in the sera of patients with BA relative to infants with non-BA cholestatic disorders.

Conclusions: Circulating levels of the miR-200b/429 cluster are elevated in infants with BA and have promising diagnostic clinical performance.

Trial registration: NCT00061828.

Publication types

  • Evaluation Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Biliary Atresia / blood
  • Biliary Atresia / diagnosis*
  • Biliary Atresia / genetics
  • Biomarkers / blood
  • Cholestasis / blood
  • Cholestasis / diagnosis*
  • Cholestasis / genetics
  • Diagnosis, Differential
  • Humans
  • Hyperbilirubinemia / blood
  • Hyperbilirubinemia / diagnosis*
  • Hyperbilirubinemia / genetics
  • Infant
  • Mice
  • MicroRNAs / blood*


  • Biomarkers
  • MicroRNAs

Associated data