Abstract
Biofilms causing biomaterial-associated infection resist antibiotic treatment and usually necessitate the replacement of infected implants. Here we relate bacterial adhesion forces and the antibiotic susceptibility of biofilms on uncoated and polymer brush-coated silicone rubber. Nine strains of Staphylococcus aureus, Staphylococcus epidermidis, and Pseudomonas aeruginosa adhered more weakly to brush-coated silicone rubber (-0.05 ± 0.03 to -0.51 ± 0.62 nN) than to uncoated silicone rubber (-1.05 ± 0.46 to -5.1 ± 1.3 nN). Biofilms of weakly adhering organisms on polymer brush coatings remained in a planktonic state, susceptible to gentamicin, unlike biofilms formed on uncoated silicone rubber.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Bacterial Adhesion
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Biofilms / drug effects
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Biofilms / growth & development
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Coated Materials, Biocompatible / chemistry*
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Gentamicins / pharmacology
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Plankton / drug effects
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Plankton / growth & development
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Poloxamer / chemistry
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Prostheses and Implants / microbiology*
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Pseudomonas aeruginosa / drug effects*
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Pseudomonas aeruginosa / growth & development
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Silicone Elastomers / chemistry
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Staphylococcus aureus / drug effects*
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Staphylococcus aureus / growth & development
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Staphylococcus epidermidis / drug effects*
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Staphylococcus epidermidis / growth & development
Substances
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Anti-Bacterial Agents
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Coated Materials, Biocompatible
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Gentamicins
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Silicone Elastomers
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Poloxamer