CYP2D6 ultrarapid metabolism and early dropout from fluoxetine or amitriptyline monotherapy treatment in major depressive patients

Mol Psychiatry. 2013 Jan;18(1):8-9. doi: 10.1038/mp.2012.91. Epub 2012 Jun 26.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amitriptyline / adverse effects*
  • Amitriptyline / blood
  • Antidepressive Agents / adverse effects*
  • Antidepressive Agents / blood
  • Cytochrome P-450 CYP2D6 / genetics
  • Cytochrome P-450 CYP2D6 / metabolism*
  • Depressive Disorder, Major / blood
  • Depressive Disorder, Major / drug therapy*
  • Depressive Disorder, Major / genetics
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Female
  • Fluoxetine / adverse effects*
  • Fluoxetine / blood
  • Follow-Up Studies
  • Humans
  • Male
  • Mexico
  • Polymorphism, Genetic
  • Time Factors

Substances

  • Antidepressive Agents
  • Fluoxetine
  • Amitriptyline
  • Cytochrome P-450 CYP2D6