CYP2D6 ultrarapid metabolism and early dropout from fluoxetine or amitriptyline monotherapy treatment in major depressive patients

Mol Psychiatry. 2013 Jan;18(1):8-9. doi: 10.1038/mp.2012.91. Epub 2012 Jun 26.

Authors

E M Peñas-Lledó, H D Trejo, P Dorado, A Ortega, H Jung, E Alonso, M E G Naranjo, M López-López, A Llerena

PMID: 22733128
DOI: 10.1038/mp.2012.91

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Amitriptyline / adverse effects*
Amitriptyline / blood
Antidepressive Agents / adverse effects*
Antidepressive Agents / blood
Cytochrome P-450 CYP2D6 / genetics
Cytochrome P-450 CYP2D6 / metabolism*
Depressive Disorder, Major / blood
Depressive Disorder, Major / drug therapy*
Depressive Disorder, Major / genetics
Dose-Response Relationship, Drug
Drug Administration Schedule
Female
Fluoxetine / adverse effects*
Fluoxetine / blood
Follow-Up Studies
Humans
Male
Mexico
Polymorphism, Genetic
Time Factors

Substances

Antidepressive Agents
Fluoxetine
Amitriptyline
Cytochrome P-450 CYP2D6