Quantitative Spectroscopic Photoacoustic Imaging: A Review

J Biomed Opt. 2012 Jun;17(6):061202. doi: 10.1117/1.JBO.17.6.061202.


Obtaining absolute chromophore concentrations from photoacoustic images obtained at multiple wavelengths is a nontrivial aspect of photoacoustic imaging but is essential for accurate functional and molecular imaging. This topic, known as quantitative photoacoustic imaging, is reviewed here. The inverse problems involved are described, their nature (nonlinear and ill-posed) is discussed, proposed solution techniques and their limitations are explained, and the remaining unsolved challenges are introduced.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acoustics
  • Algorithms
  • Animals
  • Diagnostic Imaging / methods
  • Humans
  • Light
  • Microscopy, Acoustic / methods*
  • Models, Statistical
  • Molecular Imaging / methods
  • Monte Carlo Method
  • Optics and Photonics
  • Oxygen / metabolism
  • Photoacoustic Techniques / methods*
  • Reproducibility of Results
  • Scattering, Radiation
  • Spectrum Analysis / methods*


  • Oxygen