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. 2012 Jun 26;12:48.
doi: 10.1186/1471-2261-12-48.

Assessment of Central Haemomodynamics From a Brachial Cuff in a Community Setting

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Free PMC article

Assessment of Central Haemomodynamics From a Brachial Cuff in a Community Setting

David Nunan et al. BMC Cardiovasc Disord. .
Free PMC article

Abstract

Background: Large artery stiffening and wave reflections are independent predictors of adverse events. To date, their assessment has been limited to specialised techniques and settings. A new, more practical method allowing assessment of central blood pressure from waveforms recorded using a conventional automated oscillometric monitor has recently been validated in laboratory settings. However, the feasibility of this method in a community based setting has not been assessed.

Methods: One-off peripheral and central haemodynamic (systolic and diastolic blood pressure (BP) and pulse pressure) and wave reflection parameters (augmentation pressure (AP) and index, AIx) were obtained from 1,903 volunteers in an Austrian community setting using a transfer-function like method (ARCSolver algorithm) and from waveforms recorded with a regular oscillometric cuff. We assessed these parameters for known differences and associations according to gender and age deciles from <30 years to ≥80 years in the whole population and a subset with a systolic BP < 140 mmHg.

Results: We obtained 1,793 measures of peripheral and central BP, PP and augmentation parameters. Age and gender associations with central haemodynamic and augmentation parameters reflected those previously established from reference standard non-invasive techniques under specialised settings. Findings were the same for patients with a systolic BP below 140 mmHg (i.e. normotensive). Lower values for AIx in the current study are possibly due to differences in sampling rates, detection frequency and/or averaging procedures and to lower numbers of volunteers in younger age groups.

Conclusion: A novel transfer-function like algorithm, using brachial cuff-based waveform recordings, provides robust and feasible estimates of central systolic pressure and augmentation in community-based settings.

Figures

Figure 1
Figure 1
Blood pressure (left panel) and pulse pressure and its amplification (right panel) averaged for deciles of age for males. Symbols represent peripheral systolic (▴), diastolic (●) and central systolic (Δ) blood pressures (left panel); peripheral (▴) and central (Δ) pulse pressure and their amplification ratio (♦) (right panel).
Figure 2
Figure 2
Blood pressure (left panel) and pulse pressure and its amplification (right panel) averaged for deciles of age for females. Symbols represent peripheral systolic (▴), diastolic (●) and central systolic (Δ) blood pressures (left panel); peripheral (▴) and central (Δ) pulse pressures and their amplification ratio (♦) (right panel).
Figure 3
Figure 3
Regression curves representing the effect of age on augmentation pressure and index. Symbols represent augmentation pressure and augmentation index for males (▴ andΔ, solid line) and females (■ and □, dashed lines).
Figure 4
Figure 4
Observed values for augmentation index: mean value according to age and blood pressure (BP) category AIx, augmentation index.

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