HLA class II and T cell receptor gene polymorphisms in psoriatic arthritis and psoriasis

J Rheumatol. 1990 Nov;17(11):1487-90.


HLA-DRB, DQA and DQB genes as well as the T cell receptor (TcR) alpha, beta, and gamma genes were studied by Southern blot analysis of genomic DNA from patients with psoriatic arthritis (PsA) and psoriasis alone (Ps). A subtype of DR7, DR7a, was found in 38.8% of patients with PsA, 41.5% of patients with Ps, and in 8% of healthy individuals (N) (PsA vs N: pc = 0.0002, RR = 7.1; Ps vs N: pc = 0.0002, RR = 7.9). No association with TcR genes was found. Our findings suggest either that the DR7a allele may be in linkage disequilibrium with HLA-Cw6 or that it may be an important susceptibility factor for PsA and Ps.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Arthritis, Psoriatic / genetics
  • Arthritis, Psoriatic / immunology*
  • Blotting, Southern
  • Female
  • Histocompatibility Antigens Class II / analysis*
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Genetic*
  • Psoriasis / genetics
  • Psoriasis / immunology*
  • Receptors, Immunologic / genetics*
  • T-Lymphocytes / metabolism*


  • Histocompatibility Antigens Class II
  • Receptors, Immunologic