Decorin: a guardian from the matrix

Am J Pathol. 2012 Aug;181(2):380-7. doi: 10.1016/j.ajpath.2012.04.029. Epub 2012 Jun 23.


Decorin, an archetypal member of the small leucine-rich proteoglycan gene family, has a broad binding repertoire that encompasses matrix structural components, such as collagens, and growth factors, particularly those that belong to the transforming growth factor-β ligand superfamily. Within the tumor microenvironment, stromal decorin has an inherent proclivity to directly bind and down-regulate several receptor tyrosine kinases, which are often overexpressed in cancer cells. The decorin interactome commands a powerful antitumorigenic signal by potently repressing and attenuating tumor cell proliferation, survival, migration, and angiogenesis. This collection of interacting molecules also regulates key downstream signaling processes indirectly via the sequestration of growth factors or directly via the antagonism of receptor tyrosine kinases. We propose that decorin can be considered a "guardian from the matrix" because of its innate ability to oppose pro-tumorigenic cues.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Cell Transformation, Neoplastic / metabolism
  • Cell Transformation, Neoplastic / pathology
  • Decorin / metabolism*
  • Extracellular Matrix / metabolism*
  • Humans
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Neovascularization, Pathologic / metabolism
  • Stromal Cells / metabolism
  • Stromal Cells / pathology


  • Decorin